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Welcome to a discussion about Judaism and science, about fact, fiction, and faith. Now in its twelfth year, this site has already explored a wide range of issues, from archeology to zygotes and from adam (mankind) to t’filah (prayer). And we have done so unsponsored and unencumbered by any particular denomination.
Along the way, we have encountered some interesting ideas, met some fascinating people and even gained some new perspectives. And our journey has really just begun. All who are interested in a thoughtful, respectful and constructive dialogue are invited to participate.
Jews and Genetic Disorders

Credit: ‘EM Unit, UCL Medical School, Royal Free Campus’. Wellcome Images
Introduction
Victoria Gray, a Black American woman now in her mid-thirties, was just three months old when she suffered her first painful bout with sickle cell disease (SCD), a debilitating genetic blood disorder. SCD is caused by a mutation of the hemoglobin-beta (HBB) gene in chromosome 11 that alters the shape of normally flexible, round red blood cells into rigid, crescent shaped cells. When it does, the flow of red blood cells that usually deliver oxygen to bodily tissues is restricted resulting in limited oxygen delivery to tissues and associated severe pain. Until recently, treatment consisted primarily of strong pain relief medication and, also, frequent blood transfusions. SCD affects about 100,000 people in the United States, more than 90% of whom are African-American or non-Hispanic Black, and millions more worldwide.
In 2019, Ms. Gray became the first patient with any form of genetic disease to be treated by gene-editing technology known as CRISPR which modified blood cells taken from her bone marrow for subsequent infusion back into her body. Two years later, she was not only pain free, but doing well enough to no longer be part of the landmark study for which she volunteered, although she will continue to be followed for fifteen more years in order to check the long-term safety and efficacy of her treatment.
read moreLessons from Wall Fragments and a Scroll
Wall Fragments in the Jordan Valley
Most of us have no idea of what treasures might rest under our feet. And then, perhaps, the wind blows, some rain falls, a shovel turns, and you see what no human has seen in years, maybe thousands of years.
So it was just fifty-seven years ago at a site known as Deir Alla, 13 miles east of the Jordan River and 27 miles northwest of the current Jordanian capital of Amman. There and then, an Arab foreman working with a group of archaeologists led by Prof. Henk J. Franken of the University of Leiden discovered fragments of a story that had been written many centuries earlier in red and black paint on a plaster wall. Recovery, preservation, restoration, and reassembly of the plaster fragments was a multi-year effort which led first to framed reconstructions being sent to the Amman Archaeological Museum and, subsequently, the publication of a book.
What could have caused the wall to collapse and shatter? And could that cause help us understand when the wall might have fallen? The answers came from a convergence of investigations at different sites in modern Israel and Jordan, sometimes utilizing different approaches. The sites ranged from Hazor in the north of Israel to Ein Hatseva in the south. The Jordanian site of Deir Alla lies midway between the two. What these sites have in common, and in common with other sites like Gezer, Lachish, and Tell ej-Judeidah (Tel Goded), is that they all sustained damage consistent with earthquake debris in areas stratigraphically contained to the middle of the Eighth Century BCE. In 2021, the Israel Antiquities Authority (“IAA”) announced evidence in Jerusalem, as well, of a powerful ancient earthquake around that time.
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